Paliperidone palmitate: monthly depot injection for schizophrenia
نویسندگان
چکیده
منابع مشابه
Once-monthly paliperidone injection for the treatment of schizophrenia
Paliperidone palmitate is a new long-acting antipsychotic injection for the treatment of acute and maintenance therapy in schizophrenia. Paliperidone (9-hydroxyrisperidone) is the major active metabolite of risperidone and acts at dopamine D(2) and serotonin 5HT(2A) receptors. As with other atypical antipsychotics, it exhibits a high 5HT(2A):D(2) affinity ratio. It also has binding activity as ...
متن کاملCritical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia
AIMS Three-monthly injections of paliperidone palmitate (PP-3M) represent a new and recently introduced long-acting antipsychotic therapeutic option. This review focuses on available data relating to the efficacy and safety of PP-3M and its position in the current therapeutic scenario. METHOD An analysis of PubMed, Scopus, and ISI Web of Knowledge databases was conducted, and all available pa...
متن کاملLong-term tolerability of once-monthly injectable paliperidone palmitate in subjects with recently diagnosed schizophrenia
BACKGROUND A post hoc analysis from a multiphase trial with open-label transition and maintenance phases, a double-blind relapse prevention phase, and an optional open-label extension examined the long-term tolerability with continuous once-monthly injectable paliperidone palmitate 39, 78, 117, or 156 mg (25, 50, 75, or 100 mg equivalents [mg eq] of paliperidone) in subjects with recently diagn...
متن کاملOnce-monthly paliperidone palmitate in recently diagnosed and chronic non-acute patients with schizophrenia
OBJECTIVE To explore the treatment response, tolerability and safety of once-monthly paliperidone palmitate (PP1M) in non-acute patients switched from oral antipsychotics, stratified by time since diagnosis as recently diagnosed (≤3 years) or chronic patients (>3 years). RESEARCH DESIGN AND METHODS Post hoc analysis of a prospective, interventional, single-arm, multicentre, open-label, 6-mont...
متن کاملPaliperidone palmitate injection for the acute and maintenance treatment of schizophrenia in adults
PURPOSE To review the use of paliperidone palmitate in treatment of patients with schizophrenia. METHODS Published clinical trial data for the development and utilization of paliperidone palmitate for the treatment of schizophrenia were assessed in this review. Four short-term, randomized, double-blind, placebo-controlled trials investigated the efficacy of paliperidone palmitate in acute exa...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2012
ISSN: 0959-6682
DOI: 10.1002/psb.873